Overview & Definition
Bone Marrow Transplant (BMT), also known as Hematopoietic Stem Cell Transplant (HSCT), is a specialized procedure that replaces diseased or destroyed bone marrow stem cells with healthy functioning stem cells.
Types & Classification
- Autologous BMT (Using patient’s own healthy stem cells)
- Allogeneic Matched Sibling Donor (MSD) BMT
- Matched Unrelated Donor (MUD) BMT
- Haploidentical (Half-matched family donor) BMT
Underlying Causes & Risk Factors
- High-risk Blood Cancers in remission
- Relapsed Leukemia / Lymphoma
- Severe Aplastic Anemia & Bone Marrow Failure
- Thalassemia Major & Severe Sickle Cell Disease
Common Symptoms & Warning Signs
Diagnostic Evaluation
Accurate diagnosis requires comprehensive laboratory investigation under expert hematological supervision:
- 🔍 HLA Typing & High-Resolution DNA Matching
- 🔍 Pre-transplant Organ Function Workup (Echo, PFT, CT)
- 🔍 Bone Marrow Minimal Residual Disease (MRD) Testing
- 🔍 Donor Health Evaluation & Stem Cell Mobilization Check
Treatment Options & Clinical Management
Under the guidance of Dr. Saikat Datta and Dr. Sachin Bansal, treatment strategies are tailored to individual clinical severity:
- 💊 Stem Cell Mobilization & Apheresis Collection
- 💊 Conditioning Regimen (High-dose Chemotherapy +/- Total Body Irradiation)
- 💊 Infusion of Healthy Donor Hematopoietic Stem Cells
- 💊 Graft-versus-Host Disease (GvHD) Prophylaxis & Management
- 💊 Post-Transplant Engraftment & Chimerism Monitoring
Frequently Asked Questions
Patients with severe aplastic anemia, high-risk blood cancers (leukemia, myeloma), or severe thalassemia major are evaluated for BMT based on donor availability, age, and organ fitness.
Diagnosis involves detailed peripheral blood smear examination, specialized blood biomarker panels, and where indicated, bone marrow aspiration or genetic screening.
Need Expert Consultation for Bone Marrow?
Schedule an appointment at Yashoda Hospital Secunderabad or Dr KK Clinic West Marredpally.